Preimplantation genetic diagnosis for aneuploidy testing in women older than 44 years: a multicenter experience
نویسندگان
چکیده
منابع مشابه
What next for preimplantation genetic screening (PGS)? Experience with blastocyst biopsy and testing for aneuploidy.
Blastocysts more commonly have a normal karyotype than cleavage-stage embryos do. Moreover, blastocysts have also made a metabolic transition from catabolism and recycling of the oocyte's reserves and resources, processes that fuel the first 3 days of cleavage. Although not all blastocysts are karyotypically equal, it is still to be determined to what extent a mosaic karyotype might be a normal...
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The objective of this study was to assess the improvement in implantation rates after preimplantation genetic diagnosis (PGD) of numerical abnormalities for the sole indication of advanced maternal age when compared with a control group. Each PGD patient was matched to a control patient according to several parameters prior to obtaining pregnancy results. The diagnosis was based on the analysis...
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A 33-year-old woman was referred for consideration of PGD because she was a BRCA2 gene mutation carrier. She had cancer of the right breast at the age of 24 years and underwent modified radical mastectomy with axillary dissection and immediate latissimus dorsi flap reconstruction. Adjuvant chemoradiotherapy was given and she was prescribed tamoxifen for 5 years after the operation. Her paternal...
متن کاملFirst clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy.
OBJECTIVE To develop a preimplantation genetic diagnosis (PGD) protocol that allows any form of chromosome imbalance to be detected. DESIGN Case report employing a method based on whole-genome amplification and comparative genomic hybridization (CGH). SETTING Clinical IVF laboratory. PATIENT(S) A 40-year-old IVF patient. INTERVENTION(S) Polar body and blastomere biopsy. MAIN OUTCOME M...
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2017
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2017.03.007